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Staff Machine Learning and Bioinformatics Scientist (Multi-Cancer Early Detection)

NateraSan Carlos, CAMolecular Biology Informatics & Statistics
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Salary
$169,800 — $212,300 USD
Job type
Full-time
Experience
Senior · 6+ yrs
Posted
9 Oct 2026
Status
Open · checked 7d ago

About this role

Natera is hiring a Staff Machine Learning and Bioinformatics Scientist to design multi-cancer early detection models based in San Carlos, California. This full-time position suits an experienced researcher with a PhD background in quantitative fields who wants to build scalable genomic diagnostics.

Role Overview

The Research team focuses on building tests capable of detecting multiple cancers through a single blood draw. The selected professional will design core models, process large-scale multi-modal genomic datasets, and collaborate closely with clinical scientists and molecular biologists. Responsibilities span from initial prototyping to scalable implementation and clinical validation.

Key Responsibilities

Lead the development of novel statistical and machine learning methods for cancer signal detection utilizing multi-modal genomic data.
Build interpretable and well-calibrated models while setting standards for reproducibility and uncertainty estimation.
Prototype, test, and productionize machine learning models using scalable infrastructure.
Own primary technical deliverables for large projects and help direct the research roadmap.
Coordinate with molecular biologists and clinical experts to design and analyze experiments and validation studies.
Conduct code and design reviews to maintain quality standards across projects.
Translate complex computational results into clear narratives for technical and non-technical stakeholders.
Mentor junior scientists and foster a collaborative environment.

Requirements

Hold a PhD in Computer Science, Mathematics, Bioinformatics, or a related quantitative field.
Possess 6 to 12 years of post-PhD experience.
Demonstrate hands-on experience in developing novel statistical or machine learning analysis methods for complex biological data.
Show a proven track record of technical leadership and innovation in method development.
Exhibit expertise in deep learning and multimodal foundation models.
Demonstrate proficiency in Python and its scientific computing ecosystem.
Maintain scientific rigor during the R&D process with a willingness to learn new computational methods and biology.
Possess strong communication skills for cross-functional collaboration.

Nice to Have

Familiarity with DNA methylation and epigenomic data.
Prior experience working with cell-free DNA and liquid biopsy samples.
Background in cancer genomics and diagnostics.
Hands-on practice applying multimodal foundation models to biological data.

Skills and Tools

Python
Scientific computing ecosystem
Machine learning
Deep learning
Multimodal foundation models
Statistical analysis
Genomic datasets

Salary and Benefits

The base pay range for this role is $169,800 to $212,300 USD, with final compensation depending on experience, qualifications, and internal equity. Additional total rewards include an annual performance incentive bonus, long-term equity awards, comprehensive medical, dental, and vision health benefits, a 401(k) plan with company match, generous paid time off, company holidays, free employee and family testing, fertility care benefits, pregnancy and baby bonding leave, commuter benefits, and an employee referral program.

About the Company

Natera is a global leader in cell-free DNA testing dedicated to oncology, women's health, and organ health. The organization aims to make personalized genetic testing part of standard medical care to enable earlier interventions. The workforce includes statisticians, geneticists, medical doctors, laboratory scientists, and software engineers.

How to Apply

Interested candidates should apply directly on the official Natera careers page.

Skills and tech stack

Questions candidates ask

What is the salary range for this position?

The base salary range is $169,800 to $212,300 USD, with final pay determined by experience, qualifications, and internal equity.

What education level is required?

A PhD in Computer Science, Mathematics, Bioinformatics, or a related quantitative field is required.

How many years of experience are needed?

Candidates must have 6 to 12 years of experience post-PhD.

Where is the job located?

The position is located in San Carlos, CA.

What benefits are included in the total rewards program?

Benefits include an annual performance bonus, equity awards, comprehensive health coverage, a 401(k) with company match, paid time off, free testing, fertility care, and bonding leave.

Ready to apply?

The application is on the official Natera careers page.

Apply on company site