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Member of Technical Staff - System Engineering

PhyloSouth San FranciscoTechnical Staff
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Salary
$200K - $300K USD
Job type
Full-time
Posted
5 Apr 2026
Status
Open · checked 7d ago

About this role

The Member of Technical Staff - System Engineering position at Phylo is a full-time infrastructure role based in South San Francisco, offering a salary between $200,000 and $300,000 per year. This opportunity is ideal for engineers with a background in distributed systems who want to build the core infrastructure for an agentic AI platform transforming biomedical research.

Role Overview

Phylo is looking for an infrastructure engineer to design and operate the underlying systems that drive its agentic AI platform in production environments. The selected candidate will formulate and establish the distributed systems, compute environments, and service architectures required to run AI agents reliably at scale across cloud-native and enterprise settings. As part of an AI-native engineering team that utilizes coding agents heavily, the professional in this role will operate in a fast-paced environment focused on engineering excellence.

Key Responsibilities

Formulate and construct production systems that orchestrate agent execution and support AI-driven scientific workloads.
Construct and manage scalable, dependable infrastructure across cloud, hybrid, and on-premises enterprise platforms.
Engineer systems dedicated to sandboxed execution, secure task isolation, and managed compute environments while establishing security, access control, and compliance foundations for enterprise deployments.
Administer storage and data architectures for large-scale scientific operations, incorporating distributed file systems, object storage, and databases.
Collaborate directly with machine learning and science groups to transition computational workflows into resilient, production-grade distributed architectures.

Requirements

Three or more years of professional industry experience specializing in backend, infrastructure, or distributed systems engineering.
Proficient programming capabilities in at least one language such as Python, Go, or Rust.
Practical background in designing and running distributed systems within production environments.
Extensive hands-on familiarity with containerization and Kubernetes.
Proficiency using infrastructure-as-code software like Terraform or Pulumi.
Operational expertise running systems on major cloud platforms including AWS, GCP, or Azure.
Direct experience constructing or managing large-scale distributed file systems, storage solutions, or databases in production.
Ability to independently own systems end-to-end within a fast-moving and high-autonomy workplace.

Nice to Have

Background developing research and development infrastructure within the pharmaceutical or biotechnology sectors.
Familiarity supporting data-intensive scientific computing, bioinformatics, high-performance computing, or machine learning workloads.
Experience working with job orchestration, task scheduling, or workflow engine utilities.
Knowledge of sandboxed or isolated execution frameworks such as gVisor, Kata Containers, or Firecracker.
Exposure to distributed storage, monitoring systems, or high-performance compute environments.

Skills and Tools

Python
Rust
Kubernetes
Terraform
AWS, GCP, and Azure
Distributed Systems and Storage Platforms

Salary and Benefits

Competitive annual salary ranging between $200,000 and $300,000 alongside equity share.
Comprehensive medical, dental, and vision health coverage, featuring free therapy sessions and an eyewear stipend.
401(k) retirement plan availability for long-term financial security.
Unlimited paid time off policy for U.S.-based employees.
Provided daily lunch and snacks while working from the office alongside regular team offsites and company events.

About the Company

Phylo functions as an applied research laboratory constructing agentic intelligence designed to accelerate discoveries for biomedical scientists. Supported by a $13.5M seed funding round led by investors like a16z, Menlo Ventures, and Anthropic, and advised by Nobel Prize-winning biologists, the organization focuses on commercializing the Biomni platform for the life sciences industry.

How to Apply

Interested candidates should visit the official company careers page at phylo.bio to submit an application for this opportunity.

Skills and tech stack

PythonAWSGCPAzureKubernetesRustTerraform

Questions candidates ask

What is the salary range for the Member of Technical Staff role at Phylo?

The salary for this position ranges from $200,000 to $300,000 per year, accompanied by equity share.

Where is this job located?

This role is based in South San Francisco and is an on-site position.

How much experience is required to apply?

Candidates must have 3 or more years of professional industry experience in backend, infrastructure, or distributed systems engineering.

What technical skills are needed for this position?

Required technical competencies include proficiency in a programming language like Python, Go, or Rust, hands-on experience with Kubernetes, infrastructure-as-code tools like Terraform, and experience operating systems on AWS, GCP, or Azure.

What benefits does Phylo offer to employees?

Benefits include competitive salary and equity, full medical, dental, and vision coverage with free therapy sessions, an eyewear stipend, a 401(k) plan, unlimited paid time off for U.S. employees, office lunch and snacks, and regular team offsites.

How can I apply for the Member of Technical Staff position?

You can apply directly through the official company careers page at phylo.bio.

Ready to apply?

The application is on the official Phylo careers page.

Apply on company site