Vice President, Clinical Development, Oncology
About this role
A forward-thinking clinical leader who enjoys establishing a function from the ground up and integrating advanced computational insights into oncology development will thrive in this executive capacity. Xaira Therapeutics operates at the intersection of artificial intelligence and drug discovery, building generative models to design protein and antibody therapeutics while advancing foundation models for biology. As the Vice President of Clinical Development for Oncology, this person will lead the early clinical development portfolio as programs transition from discovery into the clinic, designing first-in-human studies, establishing the internal clinical operating model, and serving as a key member of the research and development leadership team.
What you will do
- Develop and own integrated clinical development plans for priority oncology programs from candidate selection through proof of concept.
- Lead clinical strategy and content for IND and CTA submissions, including first-in-human protocols and Investigator Brochures.
- Collaborate with translational medicine teams to define biomarker strategies, target engagement endpoints, and mechanisms of action.
- Design Phase 1 studies incorporating contemporary escalation methodology, expansion cohorts, and randomized dose optimization.
- Serve as the lead clinical representative in interactions with the FDA, EMA, and other international health authorities.
- Partner with biomedical AI and data science teams to apply model-derived insights to patient selection and trial design.
- Build and mentor the internal clinical development team while establishing governance, operating models, and vendor oversight.
What you need
- Extensive experience leading clinical development strategy and execution within oncology drug discovery and development.
- Demonstrated track record of advancing programs from discovery into the clinic, including first-in-human studies and proof of concept.
- Direct experience authoring clinical content for regulatory submissions such as IND and CTA filings and interacting with health authorities.
- Strong background in designing biomarker-driven trials and translating functional genomics or computational insights into clinical hypotheses.
- Ability to build, manage, and scale clinical development functions, teams, budgets, and external vendor networks in a startup environment.
Skills and tech stack
Questions candidates ask
Where is this role located?
Xaira Therapeutics is headquartered in the San Francisco Bay Area, Seattle, and London, with this specific position based in South San Francisco, California.
What is the salary range for this position?
The salary for this role ranges from $350,000 to $407,000.
How does this role interact with AI and technology platforms?
The Vice President will apply advanced analytics and model-derived insight to development strategy, trial design, and patient selection, partnering with biomedical AI and computational biology teams to bring model-derived insight into clinical decision-making.
The application is on the official Xaira Therapeutics careers page.
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